Enhanced catalase-like activity of manganese salen complexes in water: effect of a three-dimensionally fixed auxiliary.

نویسندگان

  • Yoritada Watanabe
  • Azusa Namba
  • Naoki Umezawa
  • Masatoshi Kawahata
  • Kentaro Yamaguchi
  • Tsunehiko Higuchi
چکیده

A new Mn(Salen) complex bearing an ureido group as an auxiliary that is three-dimensionally fixed by a cyclopentane ring fused to the Salen structure was developed. This compound exhibited considerably higher catalase-like activity than the original Mn(Salen), i.e., the cyclopentane-fused Mn(Salen) without the auxiliary, under near-physiological conditions.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies.

Synthetic catalytic scavengers of reactive oxygen species (ROS) may have broad clinical applicability. In previous papers, two salen-manganese complexes, EUK-8 and EUK-134, had superoxide dismutase (SOD) and catalase activities and prevented ROS-associated tissue injury. This study describes two series of salen-manganese complexes, comparing catalytic ROS scavenging properties and cytoprotectiv...

متن کامل

Synthesis and Antioxidant Activities of [5-fluoro N, N'-bis (salicylidene) ethylenediamine] and [3, 5-fluoro N, N'-bis (salicylidene) ethylenediamine] Manganese (III) Complexes

Antioxidants act as free radical scavengers in the oxidation processes. Thus, they will certainly play diverse roles in the biological systems and the therapy of a wide variety of diseases. Regarding this fact, in the present study, we synthesized two new salen ligand compounds by the condensation of ethylendiamine and salicylaldehyde derivatives in excellent yields.The structures of ...

متن کامل

Prevention of Nonalcoholic Steatohepatitis in Rats by Two Manganese-Salen Complexes

Background: Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis with inflammation. Investigations have suggested that oxidative stress may play an important role in the progress of NAFLD to NASH. To provide further insights into beneficial effects of antioxidants in NASH prevention, we employed two manganese-supero...

متن کامل

New conjugates of β-cyclodextrin with manganese(III) salophen and porphyrin complexes as antioxidant systems.

Oxidative stress is the hallmark of several pathologies like arthritis, hypertension and many neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. In this scenario, antioxidant compounds can play a pivotal role in treating these severe pathologies. The synthesis of molecules able to mimic physiologically-relevant proteins is nowadays of particular interest. Several transiti...

متن کامل

Oxidation of nitric oxide by oxomanganese-salen complexes: a new mechanism for cellular protection by superoxide dismutase/catalase mimetics.

Manganese-salen complexes (Mn-Salen), including EUK-8 [manganese N,N'-bis(salicylidene)ethylenediamine chloride] and EUK-134 [manganese 3-methoxy N,N'-bis(salicylidene)ethylenediamine chloride], have been reported to possess combined superoxide dismutase (SOD) and catalase mimetic functions. Because of this SOD/catalase mimicry, EUK-8 and EUK-134 have been investigated as possible therapeutic a...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Chemical communications

دوره 47  شماره 

صفحات  -

تاریخ انتشار 2006